Along with vitiligo, Opzelura is also approved for atopic dermatitis, or eczema.Īdditionally, Incyte is developing experimental drugs for chronic hand eczema and hidradenitis suppurativa, or lumps that form under the skin, Stein said. An Eli Lilly drug it discovered and helped develop, Olumiant, is now approved to treat atopic dermatitis and alopecia areata.
#DEEP THERAPY CREAM FOR ECZEMA SKIN#
Though Incyte has long focused on graft-versus-host disease and on cancer, the company has more recently turned its attention to drugs for skin diseases.
Stein envisions Villaris’ drug as part of a combination regimen, with Opzelura resolving depigmentation and auremolimab preventing skin patches from reappearing. “We want to be a servant to patients in this space, so in addition to Opzelura, we want to bring them other therapies that bring them more long-term benefits,” said Steven Stein, senior director for translational sciences at Incyte, in an interview. Villaris’ drug does so by targeting an inflammatory protein receptor called IL-15, which helps regulate those T cells. Called auremolimab, it’s an experimental antibody that targets and depletes levels of certain types of T cells that retain “autoimmune memory” of the location of white spots in the skin. Villaris Therapeutics, based in Cary, N.C., has been developing a treatment that’s meant to last longer. The drug isn’t a cure, however, and it’s not clear how pigmentation may change if patients stop taking the drug, or take it less frequently. Opzelura is now cleared to treat the most common form of vitiligo, and has shown in testing it can repigment the skin of people with the disease. But Incyte was successful in developing the active ingredient in Jakafi, ruxolitinib, into a topical cream sold under the brand name Opzelura. Few treatments are available to treat vitiligo, which causes patches of skin discoloration.
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